DESCOVY for PrEP® was studied in the largest HIV prevention trial of its kind

What is DESCOVY for PrEP?

DESCOVY for PrEP (pre-exposure prophylaxis) is a once-daily prescription medicine for adults and adolescents at risk of HIV. It helps lower the chances of getting HIV through sex.

DESCOVY for PrEP is not for everyone:

  • It is not for use in people assigned female at birth who are at risk of getting HIV from vaginal sex, because its effectiveness has not been studied.
  • You must be HIV-negative before and while taking DESCOVY for PrEP.

Talk to a healthcare provider about your risk for HIV and if DESCOVY for PrEP may be an option for you.

The DISCOVER trial studied the efficacy and safety of DESCOVY for PrEP compared to TRUVADA®*

All study participants were either men who have sex with men or transgender women who have sex with men.

The DISCOVER trial recruited people who were among the most at risk for getting HIV through sex. The study included real people with diverse backgrounds and sexual practices who didn't always use condoms, and some participants had sexually transmitted infections (STIs).

*TRUVADA (emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg) tablets.

Why does it matter if people in the study had an STI?

Because some STIs, like gonorrhea, chlamydia, or syphilis, can increase the risk of getting HIV. That's why your healthcare provider will test you regularly for STIs.

Everyone in the DISCOVER trial was tested regularly, so STIs were quickly identified and treated.

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The DISCOVER trial included a broad range of people:

Learn about financial assistance for DESCOVY® (emtricitabine and tenofovir alafenamide) for PrEP (pre-exposure prophylaxis)

5000+ ADULT
PARTICIPANTS

Learn about financial assistance for DESCOVY® (emtricitabine and tenofovir alafenamide) for PrEP (pre-exposure prophylaxis)

94 STUDY SITES

Learn about financial assistance for DESCOVY® (emtricitabine and tenofovir alafenamide) for PrEP (pre-exposure prophylaxis)

11 COUNTRIES

People in the study had significant HIV risk prior to and during the study, including testing positive for other STIs.

Do not take DESCOVY for PrEP if you already have HIV-1 or if you do not know your HIV-1 status. If you have HIV-1, you need to take other medicines with DESCOVY to treat HIV-1. If you have HIV-1 and take only DESCOVY, your HIV-1 may become harder to treat now and in the future.

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99.7% of people taking DESCOVY for PrEP in the trial stayed HIV-negative

The DISCOVER trial showed that DESCOVY for PrEP worked as well as TRUVADA.

The results were analyzed when everyone had been in the study for at least 1 year, and half of the people had been in the study for at least 2 years. At that point:

Number 7 Icon

7 out of 2670 people taking DESCOVY®

tested HIV-positive during the clinical study.

99.7% Icon

99.7% on DESCOVY

stayed HIV-negative.

Number 15 Icon

15 out of 2665 people taking TRUVADA®

tested HIV-positive during the clinical study.

99.4% Icon

99.4% on TRUVADA

stayed HIV-negative.

1 of these 7 people was suspected to have HIV before the study began.

4 of these 15 people were suspected to have HIV before the study began.

17% of people in the study, or about 900 people, were taking TRUVADA just before the study began. Half of these people were switched to taking DESCOVY, and the other half continued to take TRUVADA during the study.§

Trial results were similar across subgroups of age, race, gender identity, and whether people were taking TRUVADA before the trial.

100% of people (459 people) who were taking TRUVADA before they entered the trial and began taking DESCOVY during the study remained HIV-negative.

99.8% of people (438 people) who were taking TRUVADA before they entered the trial, and remained on TRUVADA, remained HIV-negative.

§This planned analysis evaluated people who were taking TRUVADA before starting the study. It was not statistically designed to show a difference in efficacy between people who were switched to DESCOVY versus those who stayed on TRUVADA.

Common side effects in people taking DESCOVY for PrEP are diarrhea, nausea, headache, fatigue, and stomach pain. Tell your healthcare provider if you have any side effects that bother you or do not go away.

In the clinical study, PrEP medicines worked best when taken every day.

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DESCOVY for PrEP has less impact on bone and kidney health than TRUVADA

In the DISCOVER trial, DESCOVY had less impact on bone 
mineral density (BMD) compared to TRUVADA

Bone mineral density is a good gauge of bone health. For people taking DESCOVY in the DISCOVER trial, their bone health was less impacted, and they were better able to maintain BMD, compared to those taking TRUVADA.

Bone health is important and, for most people, our bones actually continue to grow into our 30s. So, whether your bones are still growing or you're more focused on maintaining their strength, DESCOVY for PrEP can help protect you against HIV just as effectively as TRUVADA for PrEP® with less impact on bone health.

Compared to TRUVADA,

DESCOVY had less impact on BMD

LUMBAR SPINE

DESCOVY 159 People
+0.5%


TRUVADA 160 People
-1.1%

HIP BONE

DESCOVY 158 People
+0.2%


TRUVADA 158 People
-1.0%

BMD is a key indicator of bone health. BMD was measured in some study participants when they entered the study and again at 1 year from the start of the study.

The long-term significance of these changes in BMD is not known.

People who took DESCOVY experienced less impact on certain kidney lab tests than those who took TRUVADA

In people taking DESCOVY, kidney function was better maintained than in those taking TRUVADA as measured by laboratory tests.

Kidneys help keep you healthy by removing waste from your blood. That's why it's important to take care of them. DESCOVY for PrEP works just as well at helping to prevent HIV as TRUVADA for PrEP, with less impact on your kidneys.

DESCOVY may cause new or worsening kidney problems, including kidney failure. Your healthcare provider should do blood and urine tests to check your kidneys before and during treatment with DESCOVY. If you develop kidney problems, your healthcare provider may tell you to stop taking DESCOVY.

Compared to TRUVADA,

DESCOVY had less impact on kidney function lab tests

DESCOVY
+1.8 mL/min eGFR


-2.3 mL/min eGFR TRUVADA

eGFR is one of the measurements that your healthcare provider may use to see how your kidneys are functioning. eGFR was measured in study participants when they entered the study and again at 1 year from the start of the study.

The long-term significance of these changes on the frequency of kidney side effects is not known.

If you're ready to learn more about DESCOVY for PrEP, have a conversation with your healthcare provider. Don't have one?

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Important Safety Information

What is the most important information I should know about DESCOVY for PrEP?

Before and while taking DESCOVY for PrEP:

  • You must be HIV-negative before you start and while taking DESCOVY for PrEP. You must get tested for HIV-1 immediately before and at least every 3 months while taking DESCOVY. If you think you were exposed to HIV-1, tell your healthcare provider right away. They may want to do more tests to confirm that you are still HIV-negative.
  • Many HIV-1 tests can miss HIV-1 infection in a person who has recently become infected. Tell your healthcare provider if you had a flu-like illness within the last month before starting or while taking DESCOVY. Symptoms of new HIV-1 infection include tiredness, fever, joint or muscle aches, headache, sore throat, vomiting, diarrhea, rash, night sweats, and/or enlarged lymph nodes in the neck or groin.
  • DESCOVY by itself is not a complete treatment for HIV-1. Do not take DESCOVY for PrEP unless you are confirmed to be HIV-1 negative.
  • DESCOVY does not prevent other sexually transmitted infections (STIs). Practice safer sex by using a latex or polyurethane condom to reduce the risk of getting STIs.
  • To further help reduce your risk of getting HIV-1:
    • Do not miss any doses of DESCOVY. Missing doses may increase your risk of getting HIV-1.
    • Know your HIV status and the HIV status of your partners. If your partner is living with HIV, your risk of getting HIV is lower if your partner consistently takes HIV treatment every day.
    • Get tested for other STIs. Some STIs make it easier for HIV-1 to infect you.
    • Talk to your healthcare provider about all the ways to help reduce HIV risk.

DESCOVY can cause serious side effects:

  • Worsening of hepatitis B (HBV) infection. Your healthcare provider will test you for HBV. If you have HBV and stop taking DESCOVY, your HBV may suddenly get worse. Do not stop taking DESCOVY without first talking to your healthcare provider, as they will need to check your health or give you HBV medicine.

Who should not take DESCOVY for PrEP?

Do not take DESCOVY for PrEP if you:

  • Already have HIV-1 or if you do not know your HIV-1 status. If you have HIV-1, you need to take other medicines with DESCOVY to treat HIV-1. If you have HIV-1 and take only DESCOVY, your HIV-1 may become harder to treat now and in the future.

What are the other possible side effects of DESCOVY for PrEP?

Serious side effects of DESCOVY may also include:

  • Kidney problems, including kidney failure. Your healthcare provider should do blood and urine tests to check your kidneys before and during treatment with DESCOVY. If you develop kidney problems, your healthcare provider may tell you to stop taking DESCOVY.
  • Too much lactic acid in your blood (lactic acidosis), which is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat.
  • Severe liver problems, which in rare cases can lead to death. Tell your healthcare provider right away if you get these symptoms: skin or the white part of your eyes turns yellow, dark "tea-colored" urine, light-colored stools, loss of appetite for several days or longer, nausea, or stomach-area pain.

Common side effects in people taking DESCOVY for PrEP are diarrhea, nausea, headache, fatigue, and stomach pain. Tell your healthcare provider if you have any side effects that bother you or do not go away.

What should I tell my healthcare provider before taking DESCOVY for PrEP?

  • All your health problems. Be sure to tell your healthcare provider if you have or have had any kidney or liver problems, including hepatitis.
  • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DESCOVY may interact with other medicines. Keep a list of all your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call .

What is DESCOVY for PrEP?

DESCOVY for PrEP (pre-exposure prophylaxis) is a once-daily prescription medicine for adults and adolescents at risk of HIV. It helps lower the chances of getting HIV through sex.

DESCOVY for PrEP is not for everyone:

  • It is not for use in people assigned female at birth who are at risk of getting HIV from vaginal sex, because its effectiveness has not been studied.
  • You must be HIV-negative before and while taking DESCOVY for PrEP.

Talk to a healthcare provider about your risk for HIV and if DESCOVY for PrEP may be an option for you.

Please see Important Facts about DESCOVY for PrEP®, including important warnings.