IS A TREATMENT
THAT CONTAINS DESCOVY®
RIGHT FOR YOU?

One of the most important HIV-1 treatment goals is to lower the amount of virus in your blood to undetectable—a level so low it can’t be measured in a lab test.

For people new to treatment

In clinical studies of adults taking an HIV-1 treatment for the first time, 92% of people who took DESCOVY® as the foundation of a complete treatment* reached undetectable (less than 50 copies/mL).

Adults Who Were Undetectable At 1 Year

As the foundation of a complete HIV-1 treatment,* DESCOVY was proven effective in a diverse group of people ages 12 years and older, men and women, and people of different races and ethnicities.

In the same clinical studies of adults, people who took DESCOVY* with other medicines increased their number of CD4 T-cells as effectively as the other approved HIV-1 treatment.

Average Increase of CD4 T-cells After 1 Year

*In these studies, DESCOVY was combined with two other medicines (elvitegravir and cobicistat) to make a complete, once-a-day treatment.

The other treatment in these studies was STRIBILD® (elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate).

CD4 T-cell increases shown in cells/mm3. The mean baseline CD4 T-cell count for study patients was 427 cells/mm3.

For people replacing their current HIV-1 treatment

In a clinical study of adults replacing their current HIV-1 treatment, 96% of people who took DESCOVY® as the foundation of a complete HIV-1 treatment* stayed undetectable.

Patients in the study had an undetectable viral load (less than 50 copies/mL) for 6 months or more on their current HIV-1 treatment. They also had to meet certain other requirements as determined by a healthcare provider in order to replace their current HIV-1 medicines with a complete treatment that contains DESCOVY.

Adults Who Were Undetectable At 1 Year

DESCOVY worked as well as the other approved medicines. In this study, the difference in the results was largely due to the higher number of patients who remained on their current HIV-1 treatment and dropped out of the study.

In the same clinical study, adults who took DESCOVY as the foundation of their HIV-1 treatment* maintained the average number of CD4 T-cells as effectively as the other approved HIV-1 treatments.

Average Increase of CD4 T-cells After 1 Year

*In these studies, DESCOVY was combined with two other medicines (elvitegravir and cobicistat) to make a complete, once-a-day treatment.

The other treatments in this study were STRIBILD, ATRIPLA® (efavirenz, emtricitabine, and tenofovir disoproxil fumarate), or TRUVADA® (emtricitabine and tenofovir disoproxil fumarate) + Reyataz (atazanavir) + cobicistat or ritonavir.

CD4 T-cell increases shown in cells/mm3. The mean baseline CD4 T-cell count for study patients was 705 cells/mm3.

Talk to your healthcare provider about what to expect when taking DESCOVY.

Before taking DESCOVY, tell your healthcare provider if you:

  • have or have had liver problems, including hepatitis B virus infection
  • have or have had kidney problems
  • have or have had bone problems
  • have or have had any other medical conditions

Avoid doing things that can spread HIV-1 infection to other people.

  • Do not share items that can have blood or body fluids on them, like needles, other injection equipment, razor blades, or toothbrushes.
  • Always practice safer sex. Use protection, like a latex or polyurethane condom, when having any sexual contact.

Being undetectable is one way to help prevent the spread of HIV-1. Ask your healthcare provider about all the steps you should take to prevent passing HIV-1 to other people.

Important Safety Information

What is the most important information I should know about DESCOVY®?

DESCOVY may cause serious side effects:

  • Buildup of an acid in your blood (lactic acidosis), which is a serious medical emergency. Symptoms of lactic acidosis include feeling very weak or tired, unusual muscle pain, trouble breathing, stomach pain with nausea or vomiting, feeling cold (especially in your arms and legs), feeling dizzy or lightheaded, and/or a fast or irregular heartbeat.
  • Serious liver problems. The liver may become large and fatty. Symptoms of liver problems include your skin or the white part of your eyes turning yellow (jaundice); dark "tea-colored" urine; light-colored bowel movements (stools); loss of appetite; nausea; and/or pain, aching, or tenderness on the right side of your stomach area.
  • You may be more likely to get lactic acidosis or serious liver problems if you are female, very overweight, or have been taking DESCOVY for a long time. In some cases, lactic acidosis and serious liver problems have led to death. Call your healthcare provider right away if you have any symptoms of these conditions.
  • Worsening of hepatitis B (HBV) infection. DESCOVY is not approved to treat HBV. If you have both HIV-1 and HBV and stop taking DESCOVY, your HBV may suddenly get worse. Do not stop taking DESCOVY without first talking to your healthcare provider, as they will need to monitor your health.

What are the other possible side effects of DESCOVY?

Serious side effects of DESCOVY may also include:

  • Changes in body fat, which can happen in people taking HIV-1 medicines.
  • Changes in your immune system. Your immune system may get stronger and begin to fight infections. Tell your healthcare provider if you have any new symptoms after you start taking DESCOVY.
  • Kidney problems, including kidney failure. Your healthcare provider should do blood and urine tests to check your kidneys. Your healthcare provider may tell you to stop taking DESCOVY if you develop new or worse kidney problems.
  • Too much lactic acid in your blood (lactic acidosis), which is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat.
  • Severe liver problems, which in rare cases can lead to death. Tell your healthcare provider right away if you get these symptoms: skin or the white part of your eyes turns yellow, dark "tea-colored" urine, light-colored stools, loss of appetite for several days or longer, nausea, or stomach-area pain.

What should I tell my healthcare provider before taking DESCOVY?

  • All your health problems. Be sure to tell your healthcare provider if you have or have had any kidney, bone, or liver problems, including hepatitis virus infection.
  • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect how DESCOVY works. Keep a list of all your medicines and show it to your healthcare provider and pharmacist. Ask your healthcare provider if it is safe to take DESCOVY with all of your other medicines.
  • If you are pregnant or plan to become pregnant. It is not known if DESCOVY can harm your unborn baby. Tell your healthcare provider if you become pregnant while taking DESCOVY.
  • If you are breastfeeding (nursing) or plan to breastfeed. Do not breastfeed. HIV-1 can be passed to the baby in breast milk.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call .

What is DESCOVY?

DESCOVY is a prescription medicine that is used together with other HIV-1 medicines to treat HIV-1 in people 12 years and older. DESCOVY is not for use to help reduce the risk of getting HIV-1 infection. DESCOVY combines 2 medicines into 1 pill taken once a day. Because DESCOVY by itself is not a complete treatment for HIV-1, it must be used together with other HIV-1 medicines.

DESCOVY does not cure HIV-1 infection or AIDS. To control HIV-1 infection and decrease HIV-related illnesses, you must keep taking DESCOVY. Ask your healthcare provider if you have questions about how to reduce the risk of passing HIV-1 to others. Always practice safer sex and use condoms to lower the chance of sexual contact with body fluids. Never reuse or share needles or other items that have body fluids on them.

Please see Important Facts about DESCOVY, including important warnings.